Get FREE Price Alerts

Subscribe to our weekly cruise deals email and enjoy FREE price change alerts and updates for this cruise and others like it.

We promise to protect your privacy and personal data. You can review our privacy policy here.

Modify Your Choices
Vacation Type


Filters
Destination
- Panama Canal
Travel Dates
Narrow Date Range
Departure Port
- San Diego, CA
Cruise Length
- All Durations
Cruise Line
- All Cruise Lines
Cruise Ships
- All Cruise Ships

Cruises from San Diego


Sailings per page
12 Matched Sailings
Departing
Itinerary and Ship
Length
Save to
Favorites
Priced from

Jan 30, 2027

(Saturday)

15 Night Panama Canal Cruise

Zuiderdam
Holland America Line
Starts: San Diego, California
Ends: Miami, Florida
Ports of Call:
San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puerto Quetzal, Fuerte Amador...

15 Nights


Add to Favorites
Compare Favorites
from

$1,699

per person
(double occupancy)
Includes taxes & fees
Learn More

Feb 13, 2027

(Saturday)

16 Night Panama Canal Cruise

Norwegian Star
Norwegian Cruise Line
Starts: San Diego, California
Ends: Miami, Florida
Ports of Call:
San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Puntarenas, Panama City...

16 Nights


Add to Favorites
Compare Favorites
from

$1,709

per person
(double occupancy)
Includes taxes & fees
Learn More

Dec 19, 2026

(Saturday)

15 Night Panama Canal Holiday Cruise

Zaandam
Holland America Line
Starts: San Diego, California
Ends: Fort Lauderdale, Florida
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Huatulco, Puerto Quetzal, Puerto Caldera...

15 Nights


Add to Favorites
Compare Favorites
from

$1,899

per person
(double occupancy)
Includes taxes & fees
Learn More

Jan 29, 2027

(Friday)

16 Night Panama Canal Ocean to Ocean Cruise

Island Princess
Princess Cruises
Starts: San Diego, California
Ends: Fort Lauderdale, Florida
Ports of Call:
San Diego, Puerto Vallarta, Huatulco, Puerto Chiapas, Puntarenas, Fuerte Amador...

16 Nights


Add to Favorites
Compare Favorites
from

$1,919

per person
(double occupancy)
Includes taxes & fees
Learn More

Nov 06, 2026

(Friday)

14 Night Eastbound Panama Canal Cruise

Disney Magic
Disney Cruises
Starts: San Diego, California
Ends: Galveston, Texas
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Cruising the Panama Canal, Cartagena, Georgetown ...

14 Nights


Add to Favorites
Compare Favorites
from

$2,477

per person
(double occupancy)
Includes taxes & fees
Learn More

Oct 07, 2027

(Thursday)

15 Night Panama Canal Eastward Cruise

Serenade of the Seas
Royal Caribbean Cruises
Starts: San Diego, California
Ends: Tampa, Florida
Ports of Call:
San Diego, Puerto Vallarta, Puerto Quetzal, Puntarenas, Cruising the Panama Canal, Cartagena...

15 Nights


Add to Favorites
Compare Favorites
from

$2,507

per person
(double occupancy)
Includes taxes & fees
Learn More

Dec 18, 2027

(Saturday)

15 Night Panama Canal Holiday Cruise

Zaandam
Holland America Line
Starts: San Diego, California
Ends: Miami, Florida
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Manzanillo, Huatulco, Puerto Caldera...

15 Nights


Add to Favorites
Compare Favorites
from

$2,604

per person
(double occupancy)
Includes taxes & fees
Learn More

Nov 04, 2027

(Thursday)

14 Night Eastbound Panama Canal Cruise

Disney Magic
Disney Cruises
Starts: San Diego, California
Ends: Galveston, Texas
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Fuerte Amador, Cruising the Panama Canal, Cartagena...

14 Nights


Add to Favorites
Compare Favorites
from

$2,700

per person
(double occupancy)
Includes taxes & fees
Learn More

Oct 07, 2027

(Thursday)

16 Night Panama Canal Cruise

Eurodam
Holland America Line
Starts: San Diego, California
Ends: Fort Lauderdale, Florida
Ports of Call:
San Diego, Cabo San Lucas, Acapulco, Huatulco, Puerto Chiapas, Puerto Quetzal, Puerto Caldera...

16 Nights


Add to Favorites
Compare Favorites
from

$2,769

per person
(double occupancy)
Includes taxes & fees
Learn More

May 24, 2027

(Monday)

17 Night Panama Canal and Latin America Mexico Costa Rica and Colombia Cruise

Azamara Quest
Azamara Cruises
Starts: San Diego, California
Ends: Miami, Florida
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Puerto Quetzal, Acajutla, Puntarenas...

17 Nights


Add to Favorites
Compare Favorites
from

$4,159

per person
(double occupancy)
Includes taxes & fees
Learn More

May 24, 2027

(Monday)

35 Night San Diego to London Grand Voyage Cruise

Azamara Quest
Azamara Cruises
Starts: San Diego, California
Ends: Tilbury, United Kingdom
Ports of Call:
San Diego, Cabo San Lucas, Puerto Vallarta, Puerto Quetzal, Acajutla, Puntarenas...

35 Nights


Add to Favorites
Compare Favorites
from

$9,949

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 09, 2027

(Monday)

25 Night San Diego to New York City Cruise

Crystal Serenity
Crystal Cruises
Starts: San Diego, California
Ends: New York, New York
Ports of Call:
San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas...
Special Promotions

25 Nights


Add to Favorites
Compare Favorites
from

$10,400

per person
(double occupancy)
Includes taxes & fees
Learn More



Overlay Title