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Cruises from St Louis


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Aug 14, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


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$5,635

per person
(double occupancy)
Includes taxes & fees
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Sep 10, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Symphony
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


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from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 11, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
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from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 25, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
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from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 27, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 10, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 24, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 18, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 25, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Jul 10, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...
Theme Cruise

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Jul 24, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 07, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 11, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Jul 14, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Jul 09, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...
Theme Cruise

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Jul 23, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 06, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 20, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 03, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 08, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 22, 2028

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 18, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 17, 2027

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Sep 04, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Serenade
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More

Aug 28, 2026

(Friday)

8 Night Upper Mississippi Cruise and Land Tour

American Melody
American Cruise Lines
Starts: St Louis, Missouri
Ends: St Paul, Minnesota
Ports of Call:
St Louis, Alton Illinois, Hannibal, Cruising the Mississippi River, Muscatine, Dubuque, Winona...

8 Nights


Add to Favorites
Compare Favorites
from

$5,635

per person
(double occupancy)
Includes taxes & fees
Learn More



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